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IUPAC Prize for Young Chemists - 2002
Honorable Mention



Izabela Tworowska receives one of four Honorable Mention awards associated with the IUPAC Prize for Young Chemists, for her Ph.D. thesis work entitled "Chemistry and Stereochemistry of Nucleosidyl Phosphorofluoridates and their Structural Analogues."

Current address (at the time of application)

Center of Molecular and Macromolecular Studies
Polish Academy of Sciences, Sienkiewicza 112
P-90363 Lodz, Poland

E-mail: [email protected], [email protected], or [email protected]

Academic degrees

  • Ph.D. Polish Academy of Sciences, Lodz, Poland, 2001
  • B.Sc. Medical University of Lodz, Faculty of Pharmacy, 1992

Ph.D. Thesis

Title Chemistry and Stereochemistry of Nucleosidyl Phosphorofluoridates and their Structural Analogues
Advisers Prof. Jan Michalski
Thesis Committee Prof. M. Mikolajczyk, Polish Academy of Sciences, Lodz; Prof. M. Markiewicz, Polish Academy of Sciences, Poznan; Prof. A. Malkiewicz, Technical University, Lodz; Prof. M. Potrzebowski, Polish Academy of Sciences, Lodz; Prof. P. Kubisa, Polish Academy of Sciences, Lodz; Prof. A. Bodalski, Technical University, Lodz; Prof. C. Cierniewski, Medical University, Lodz; Prof. L. Slusarski, Technical University, Lodz; and Prof. R. Skrowronski, University, Lodz, Poland.


Oligonucleotides containing modified internucleotide bond have drawn my attention owing to their potential biochemical and therapeutical usage.[1] An introduction of a fluorine group into a phosphoroorganic compounds causes remarkable changes of their chemical and biochemical properties. It was reported that 5'-fluorophosphates inhibit the phosphorylation reaction catalyzed by adenylate kinases and inhibit HIV reproduction in cell cultures.[2] I anticipated that phosphorofluoridates incorporated into oligonucleotides could be useful in the studies of biological functions of nucleic acids.

<Download full-text essay, pdf file-119KB>


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