Number: 2002-035-1-500
Title: Solubility data of compounds relevant to human health.
Solubility of substances related to urolithiasis
Series: Solubility Data Series; editor-in-chief: Mark
Salomon
Task Group
Chairmen: E. Königsberger
and L.-C. Königsberger
Objective/Description:
The prevention and treatment of crystal deposition in the human body
are based on the understanding of the physico-chemical properties underlying
the precipitation of the substances involved. Amongst these properties,
the solubilities of the crystals are very important. In the scope of
urolithiasis, there are more than 20 different types of kidney stones
composed of calcium oxalate hydrates (mono-, di- and trihydrate), ammonium
magnesium phosphate (struvite), calcium phosphates (hydroxyapatite and
brushite), uric acid and urates, cystine and xanthine. Solubilities
of these substances can be incorporated in databases of sophisticated
software packages that permit solubility calculations in artificial
urine solutions. The results of these simulations would lead to some
understanding and/or useful suggestions regarding the cause, prevention
and treatment of renal or bladder calculi. Nevertheless, proper modelling
of the solubilities of these substances requires reliable solubility
constants. Thus it is necessary to critically assess the literature
values reported for these substances. Recently, two reviews on this
subject have been published:
[1] E. Königsberger and L.-C. Tran-Ho, Solubility of substances
related to urolithiasis - Experiments and computer modelling. Current
Topics in Solution Chemistry, 2:183-202 (1997).
[2] E. Königsberger and L.-C. Königsberger, Thermodynamic
modelling of crystal deposition in humans. Pure
Appl. Chem.,
73:785-797 (2001).
Progress:
Papers related to this project:
G. Sadovska, I. Kron and E. Königsberger. Solubility of uric acid
in lithium chloride solutions. Monatsh. Chem., 134:787-790,
2003. [doi:10.1007/s00706-002-0588-2]
> Nov 2004 report update (pdf
file - 10KB)
To be published as part of the IUPAC-NIST Solubility Data Series. in
J. Phys. Chem. Ref. Data; estimated to be completed during 2006/7.
> May 2006 report update (pdf
file - 13KB)
> July 2007 report update (pdf
file - 8KB)
1 book and 2 book chapters related to the project were published recently:
- Biomineralization
- Medical Aspects of Solubility. E. Königsberger and L.C. Königsberger
(eds.) Wiley, 2006, 284 pp.
- E. Königsberger and L.C. Königsberger. Solubility phenomena
related to normal and pathological biomineralisation processes. In:
Biomineralization - Medical Aspects of Solubility. E. Königsberger
and L.C. Königsberger (eds.), John Wiley & Sons, 1-37, 2006.
- E. Königsberger and L.-C. Königsberger. Solubility and
body fluids. In: Thermodynamics,
Solubility and Environmental Issues. T. Letcher (ed.), Elsevier,
445-461, 2007.
Last Update: 16 October 2007
>
View SDS published Volumes
<project announcement published in
Chem. Int.
25(3), 2003>