Chemistry International
Vol. 21, No. 5
September 1999
New
Books and Publications
New Book from the Royal Society of Chemistry
Drugs: Photochemistry and Photostability.
Edited by A. Albini and E. Fasani, University of Pavia, Italy.
Since Pasteur's discovery in 1846, scientists have been aware that
many drugs are photoreactive, but until recently, research in this area
had been somewhat limited. However, since the introduction of acutely
sensitive analytical methods, the realization of the need to identify
the photochemical properties of a potential drug as early in its development
as possible, and the increased attention to the phototoxic effect of
drugs, more details are becoming available.
Drugs: Photochemistry and Photostability presents the basic
elements of the science, and serves as an excellent introduction to
this emerging field of photochemistry. Detailed experimental conditions
for photostability studies are given, along with a discussion of the
recently implemented International Conference on Harmonisation (ICH)
Guidelines for drug photostability.
With contributions from international experts in the field and including
a comprehensive literature review, this book provides all the up-to-date
information needed by researchers in many fields, especially medicinal
and pharmaceutical chemistry.
Contents
Photochemistry of Drugs: An Overview and Practical Problems; Medicinal
Photochemistry (An Introduction with Attention to Kinetic Aspects);
Photoreactivity of Selected Antimalarial Compounds in Solution and in
the Solid State; Photochemistry of Diuretic Drugs in Solution; New Results
on the Photoinstability of Antimycotics; Photoreactivity versus
Activity of a Selected Class of Phenothiazines: A Comparative Study;
Photoprocesses in Photosensitizing Drugs Containing a Benzophenone-Like
Chromophore; Photostability of Coumarin; Photostabilities of Several
Chemical Compounds Used as Active Ingredients in Sunscreens; An Analytical
and Structural Study of the Photostability of Some Leukotriene B4 Antagonists;
Molecular Mechanisms of Photosensitization Induced by Drugs on Biological
Systems and Design of Photoprotective Systems; A Comparison between
the Photochemical and Photosensitizing Properties of Different Drugs;
Photostability of Drug Substances and Drug Products: A Validated Reference
Method for Implementing the ICH Photostability Study Guidelines; The
Elaboration and Application of the ICH Guideline on Photostability:
A European View; Selecting the Right Source for Pharmaceutical Photostability
Testing; Design and Validation Characteristics of the Environmental
Chambers for Photostability Testing; Design Limits and Qualification
Issues for Room-Size Solar Simulators in a GLP Environment; Actinometry:
Concepts and Experiments; trans-2-Nitrocinnamaldehyde as Chemical
Actinometer for the UV-A Range in Photostability Testing of Pharmaceuticals;
Subject Index.
ISBN: 0 85404 743 3; viii + 326 pages; Price: GBP 59.50;
Special Publication No. 225, Hardcover, 1998.
To order, contact Sales and Customer Care, The Royal
Society of Chemistry, Thomas Graham House, Science Park, Milton Road,
Cambridge, England CB4 0WF, UK; E-mail: [email protected];
Tel.: +44 1223 420066; Fax: +44 1223 423429; Web site: http://www.rsc.org
or http://www.chemsoc.org/.