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Vol.
25 No. 3
May - June 2003
Solubility
of Hydroxybenzoic Acids and Hydroxybenzoates
Hydroxybenzoic
acids and related compounds are pharmaceutically important
substances. In particular, 2-hydroxybenzoic acid has been
widely used as a medicine and a preservative for food products;
4- hydroxybenzoic acid alkyl esters have also been used as
preservatives for food. The relation between the use of these
substances and human health requires evaluation of the solubilities
of 2-, 3-, and 4-monohydroxybenzoic acids and of 4-hydroxybenzoic
acid alkyl esters in water, organic and mixed solvents. In
this project, it is also intended to evaluate the solubilities
of (a) 2- and 3-hydroxybenzoic acid in supercritical carbon
dioxide containing organic solvents such as methanol and acetone,
and (b) monohydroxybenzoates, 2,3-, 2,4-, 2,5-, 2,6-, 3,4-
and 3,5- dihydroxybenzoic acid salts of alkali, transition,
and rare earth metals in water and organic solvents.
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