Contents

Preface

Polyion Complex Micelles with Core-Shell Structure: Their Physicochemical Properties and Utilities as Functional Materials

1

Atsushi Harada, Kazunori Kataoka*

Crosslinking of Porcine Aortic Leaflets with Butane-1,4-diol Diglycidyl Ether

11

Pieter J. Dijkstra, Raymond Zeeman, Jan Feijen*

Immunprotective Therapy with Targeted Anticancer Drugs .

21

B. Ríihová*, J. Strohalm, K. Hoste, M. Jelínková, 0. Hovorka, M. Kovát, D. Plocová, M. Sírová, M. St'asty, E. Schacht, K. Ulbrich

The Lysosome/Endosome Membrane: A Barrier to Polymer-Based Drug Delivery

29

John B. Lloyd

Mechanisms of Anticancer Action of HPMA Copolymer Bound Doxorubicin

35

Tamara Minko*, Pavla Kopeceková, Jindrich Kopecek

PH-Sensitive Hemolysis by Random Copolymers of Alkyl Acrylates and Acrylic Acid

49

Niren Murthy, Isiah Chang, Pat Stayton, Allan Hoffmann*

Amphiphilic Membranes with Controlled Mesh Dimensions for Insulin Delivery.

57

Joseph P. Kennedy*, Gyorgyi Fenyvesi, Richard P. Levy, Ken S. Rosenthal

Protein Release from Poly(ortho ester) Extruded Rods .

67

Alexandra Rothen-Weinhold, John Bart, Steven Y. Ng, Hui-Rong Shen, Robert Gurny, Jorge Heller*

Treatment of Intralocular Diseases with Poly(ortho ester)-Based Drug Delivery Systems .

73

Suzanne Einmahl*, Francine Behar-Cohen, Cyros Tabatabay, Robert Gurny

Tailot-Made Biomimetic Random Copolymers for Medical Applications .

87

Claudia Gervelas, Thierry Avramoglou*, Sandrine Berlot-Moirez, Jaqueline Jozefonvicz, Marcel Jozefowicz

Immobilization of Concanavalin A to Glucose-Containing Polymers .

95

Jung Ju Kim, Kinam Park*

Selective Energy Depletion and Sensitization of Multiple Drug-Resistant Cancer Cells by Pluronic Block Copolymer .

103

Alexander V. Kabanov*, Elena V. Batrakova, Shu Li, Valerii Yu. Alakhov

Biodegradable Graft Polyesters Based on Copolymer of Lactic Acid and Glycolic Acids Grafted onto Poly(vinyl alcohol) for Oral Vaccine Delivery

113

T. Kissel*, T. Jung, W. Kamm, A. Breitenbach

Polymeric Organoiron Compounds as Prodrugs in Cancer Research.

127

E. W. Neuse

Physiological Considerations in Dosage Form Design

139

Ping-Yang Yeh*, Philip L. Smith

Sulfonamide-Containing Polymers: A New Class of pH-Sensitive Polymers and Gels

149

Seong Il Kang, Kun Na, You Han Bae*

Hydrogels for Encapsulation of Mammalin Cells

157

Jaromir Lukás*, Vera Palecková, Jaroslav Mokry, Jana Karbanová, Barbora Dvoránková