Diels_Alder reactions in water
Sijbren Otto and Jan B. F. N. Engberts
Department of Organic and Molecular Inorganic Chemistry,
Stratingh Institute, University of Groningen, Nijenborgh 4, 9747 AG
Groningen, The Netherlands
Abstract: This review illustrates how water, as an environmentally
friendly solvent, can have significant additional benefits when it is
used as a solvent for the Diels_Alder reaction. The mechanism by which
the unique properties of water enhance the rate and selectivity are
discussed. Also, possibilities for the achievement of further increases
in rate and enantioselectivity of aqueous Diels_Alder reactions through
Lewis-acid and micellar catalysis are reviewed.
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