Recent results toward the stereoselective synthesis of biologically active natural products*
Luiz C. Dias, Luciana G. de Oliveira, and Paulo R. R. Meira
Instituto de Química, Universidade Estadual de Campinas, UNICAMP, C.P. 6154, CEP 13084-971, Campinas, São Paulo, Brazil
Abstract: This paper describes the convergent and stereocontrolled asymmetric total synthesis of (+)-crocacins C and D, potent inhibitors of animal cell cultures and several yeasts and fungi, and (-)-callystatin A, a potent antitumor polyketide.
Keywords: natural product synthesis; antitumor compound; polyketides; diastereocontrol.
*Paper based on a presentation at the 16th International Conference on Organic Synthesis (ICOS-16), 11-15 June 2006, Mérida, Yucatán, México. Other presentations are published in this issue, pp. 153-291.