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Pure Appl. Chem., Vol. 70, No. 9, pp. 1647-1656, 1998

    Natural and anthropogenic environmental oestrogens:
    the scientific basis for risk assessment

    Neurotransmitters and the control of hypophyseal gonadal functions:
    possible implications of endocrine disruptors

    F. Piva and L. Martini
    of Endocrinology, University of Milano, Via Balzaretti 9, I-20133 Milano, Italy.
    E-mail: [email protected]

Abstract: The reports published so far may suggest that chemicals of plant origin or obtained by synthesis may influence the central mechanisms controlling gonadotropin secretion through a variety of different mechanisms.
Some compounds of herbal origin seem to affect the neuroendocrine system acting as estrogens (zearalenone and genistein). Also some synthetic chemicals seem to display an estrogenic influence on the neuroendocrine system (the pesticide chlordecone, some of the polychlorinated biphenyls and of the alkylphenol ethoxylates). However, other synthetic molecules may affect the central control of gonadotropin secretion acting like antiandrogens (pesticides like DDT, dioxin and vinclozolin) or by disrupting the adrenergic regulation of the hypothalamo-pituitary-gonadal axis (the pesticides chlordimeform and thiram).
These conclusions refer only to a few compounds and are largely based on indirect evidence; in many cases specific experiments are still to be performed. For many other chemicals the possible mechanism of action on the neuroendocrine system is still to be elucidated. However, the information collected so far seems to suggest that the influence exerted by environmental endocrine disruptors on the neuroendocrine system is more complex than previously anticipated.

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