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Pure Appl. Chem., Vol. 71, No. 12, pp. 2349-2365, 1999

Glossary of Terms Used in Combinatorial Chemistry

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Analytical Construct: Tool for development of chemistry on solid support whereby the desired compound is prepared in a form which facilitates analysis. This may be achieved by the insertion of an additional, orthogonal linker between the solid support and the standard linker thus allowing release of the linker-bound compound at any desired point in compound assembly1-3.

Aptamer: Oligonucleotide which displays specific binding to a protein or other target, often selected by an iterative cycle of affinity-based enrichment4-6. See also SELEX.

ArgoGel: (Trademark of Argonaut Technologies, San Carlos, California, U.S.A.) Beaded solid support with a crosslinked polystyrene core and grafted linear poly(ethylene glycol) (PEG) chains with terminal functional groups 7.

Array Synthesis: Form of parallel synthesis in which the reaction vessels are maintained in a specified spatial distribution, e.g. the wells of a 96-well plate or pins held in a rack 8-10.

Assay Equivalent: An aliquot of a library which will allow the library to be screened in a single assay. Particularly applicable to libraries prepared by split/pool procedure where it pertains to the number of particles required to sample a library. Generally consists of a specified number of library equivalents. For statistics related to this see ref. 11.

Backbone: A scaffold of approximately linear configuration. Thus in the generic structure of a tetrapeptide shown below, the repeating polyamide core structure (everything except for the R groups — see residue) constitutes the backbone.

Bead: (normally spherical) particle of solid support.

Biased Library: see Directed Library

Binning: Approach to classifying the diversity of a set of compounds by grouping related members in "bins" on the basis of common physical or structural features. Commonly applied to the analysis of a set for the completeness of coverage of the desired property space 12.

Binary Code: Relationship between a set of tags and their corresponding ligands where building block identity is denoted by the presence or absence of a given tag or set of tags (i.e. the two "bits" 1 and 0). Compare quantitative or ratio coding 13.

Building Block: One of a number of interchangeable reagents which can be used in combinatorial library synthesis, part of the structure of which becomes incorporated into the final product, i.e. its residue. See also diversity reagent.


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