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Pure Appl. Chem., Vol. 71, No. 12, pp. 2349-2365, 1999

Glossary of Terms Used in Combinatorial Chemistry

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Tag: (a) One of a set of surrogate analytes which are used in a decoding process; (b) pendant function which allows a molecule to be selected from a mixture (see phase switch) 21,99.

Tea-Bag: A type of reaction vessel consisting of a porous mesh which encloses the resin but allows passage of reagents and solvents when immersed in an appropriate secondary container. Several tea-bags may be treated in a single vessel without mixing of the enclosed resins; manipulation of multiple tea-bags allows preparation of libraries by pool/split or directed sorting techniques 105.

Template: see Scaffold

TentaGel: (Trademark of Rapp Polymere GmbH, Tubingen, Germany) Beaded solid support with a crosslinked polystyrene core and grafted linear poly(ethylene glycol) (PEG) chains with terminal functional groups 106,107.

Tether: see Linker

Thematic Library: see Directed Library

Tiered Release: see Partial Release

Traceless Linker: Type of linker which leaves no residue on the compound after cleavage, i.e. is replaced by hydrogen, as in the acid-cleavable germanium-based linker below 108-110.

> Introduction
> Notes

> References

> Alphabetical Entries

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