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Pure Appl. Chem., Vol. 71, No. 12, pp. 2349-2365, 1999

Glossary of Terms Used in Combinatorial Chemistry

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Macroporous Resin: Polymer which contains a permanent network of pores independent of the state of swelling of the resin. This class of resin thus displays much better solvent tolerance than gel-type resins 18.

Magic Angle Spinning: NMR strategy in which the tube is rotated at very high speed and at a specific angle which cancels out the line broadening effects of inhomogeneities in the sample. This yields high resolution and high sensitivity which are very useful in trace analysis or in looking at solid phase synthesis resins 60.

Markush Structure: Similar to a generic structure, but more flexible in that the substituents on the core structure need not be precisely enumerated, e.g. 'alkyl' rather than 'CH3-, CH3CH2-, CH3(CH3)CH-'.

MAS: see Magic Angle Spinning

Mask: Device which acts as a barrier to the passage of a reagent (often light — see photolithography). A pattern of holes in the mask allows selective passage of reagent and results in a corresponding pattern of reagent deposition or photodeprotection on a surface placed behind the mask. This allows the generation of spatially addressable libraries 61,62.

MPS: multiple parallel synthesis (see parallel synthesis).

Member: a) specific compound which is included in a library; b) the uncharacterized physical product of a library synthesis 14.

Merrifield Resin: p-(chloromethyl) polystyrene 63.

Mesh Size: The density of wires in a sieve. Often used as a measure of particle size, for example, of solid supports. A resin whose particle size is quoted as 100-200-mesh will pass through a 100-mesh filter but is trapped by a 200-mesh filter, and consists of particles whose diameter is between 75 and 150 mm. There are, unfortunately, several standard scales for this measurement but which differ only very slightly from one another.

Monomer: Member of a building block set which can be repeatedly incorporated into a library to give a set of compounds of repeating structure; e.g. amino acids in a peptide library.

MPS: Multiple parallel synthesis: see Parallel Synthesis

Multiple Simultaneous Synthesis: see Parallel Synthesis

Neural Network: Technique for optimizing a desired property given a set of items which have been previously characterized with respect to that property (the 'training set'). Features of members of the training set which correlate with the desired property are 'remembered and used to generate a model for selecting new items with the desired property or to predict the fit of an unknown member 64,65.

Null Reagent: Concept whereby one of a set of pools is subjected to no reaction at a particular stage of a combinatorial synthesis. It is often necessary to record this as a null event to maintain congruence in computational records of the library.

> Introduction
> Notes

> References

> Alphabetical Entries

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