Glossary of Terms Used in Combinatorial
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Unbiased Library: Library prepared
from building blocks and
scaffold chosen without bias towards
a particular target33.
Universal Library: A hypothetical
compound collection which will show activity in all assays; A library
with useful activity in many assays.
Virtual Library: A library which
has no physical existence, being constructed solely in electronic form
or on paper. The building blocks
required for such a library may not exist, and the chemical steps for
such a library may not have been tested. These libraries are used in
the design and evaluation of possible libraries48.
Virtual Screening: Selection
of compounds by evaluating their desirability in a computational model.
Also termed in silico screening17,111.
Wang Resin: Acid-cleavable resin which
generates compounds bearing a carboxylic acid. (4-hydroxymethyl)phenoxymethyl
X-Ray Photoelectron Spectroscopy
(XPS): Technique for determining the elemental composition at a solid
surface by measuring the energy of elctrons emitted in response to X-rays
of different frequency. Has been applied to solid-phase combinatorial
chemistry by incorporating a tracer atom in the linker113.